[24]. in the treatment of some diseases such as

24. Acute myeloid leukemia (AML) is a Heterogeneous  hematologic malignancy characterized by the clonal expansion of immature myeloid blasts25. LSCs are a subpopulation of leukemic cells that indicate characteristics of self-renewal, tumor-initiating and differentiation capacity. They are also thought to be responsible for chemotherapy and radiotherapy resistance and the relapse of leukemia26.There are several documents that exhibit thiosemicarbazones and their metal complexes might be efficient in the treatment of some diseases such as cancers27-35. The antiproliferative effects of TSC were once particularly ascribed to the inhibition of ribonucleotide reductase enzyme that is involved in the step of rate-limiting the synthesis of DNA. However, the mechanism of this inhibition was initially not demonstrated. The capability of thiosemicarbazones to chelate metal ions has now been recognized as the main agent in their antiproliferative properties. For example, The redox activity of Fe–thiosemicarbazone complexes is significant in their antitumor effects, resulting in oxidative damage and the inhibition of ribonucleotide reductase. In vivo studies demonstrate that some thiosemicarbazones indicate potential as chemotherapeutic factors27.

24. Acute myeloid leukemia (AML) is a Heterogeneous  hematologic malignancy characterized by the clonal expansion of immature myeloid blasts25. LSCs are a subpopulation of leukemic cells that indicate characteristics of self-renewal, tumor-initiating and differentiation capacity. They are also thought to be responsible for chemotherapy and radiotherapy resistance and the relapse of leukemia26.There are several documents that exhibit thiosemicarbazones and their metal complexes might be efficient in the treatment of some diseases such as cancers27-35. The antiproliferative effects of TSC were once particularly ascribed to the inhibition of ribonucleotide reductase enzyme that is involved in the step of rate-limiting the synthesis of DNA. However, the mechanism of this inhibition was initially not demonstrated. The capability of thiosemicarbazones to chelate metal ions has now been recognized as the main agent in their antiproliferative properties. For example, The redox activity of Fe–thiosemicarbazone complexes is significant in their antitumor effects, resulting in oxidative damage and the inhibition of ribonucleotide reductase. In vivo studies demonstrate that some thiosemicarbazones indicate potential as chemotherapeutic factors27.

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